Cellular Senescence: Unveiling the Mechanisms of Aging and Disease
Cellular senescence, a hallmark of aging, is characterized by the irreversible arrest of cell division in response to various stressors, including repeated DNA damage. Senescent cells, while initially beneficial by eliminating damaged cells and preventing tumorigenesis, can accumulate over time, contributing to various age-related diseases.
Despite significant advancements in understanding the molecular mechanisms underlying cellular senescence, researchers still face a major challenge: the lack of a universally accepted senescent cell marker. This hinders the accurate identification and quantification of senescent cells in vivo, impeding further research and therapeutic development.
At Celentis, we are committed to empowering researchers in the field of cellular senescence with innovative tools to accelerate their discoveries. Our comprehensive range of molecular senescence sensors is designed to meet the diverse needs of preclinical and basic science researchers.
Our senescence sensors have undergone rigorous validation by leading research groups across Spain, the United Kingdom, France, and Germany. Their efficacy is further supported by a groundbreaking macrostudy published in February 2024 by LEV Foundation, Beverly Hills. This study demonstrates the remarkable potential of our Nav-Gal pro-drug, a navitoclax conjugate with galactose, for senescent cell ablation. In combination with other therapies, Nav-Gal nearly doubles the lifespan of experimental animals.
Our extensive portfolio of validated senescence sensors, backed by a wealth of scientific publications, offers researchers the tools they need to unravel the complexities of cellular senescence and pave the way for novel anti-aging and disease-modifying therapies.
Advanced Senescence Sensors: Your Gateway to Anti-Aging Discoveries
At Celentis, we empower researchers to combat aging and disease with our innovative senescence sensors. Our easy-to-use molecular probes enable streamlined in vivo and ex vivo detection of senescent cells, providing unparalleled insights into the dynamics of aging and age-related pathologies.
Our advanced in vivo senescence sensors allow researchers to visualize and quantify senescent cells within the living organism, offering real-time insights into their role in aging and disease progression.
Our ex vivo senescence sensors enable researchers to isolate and characterize senescent cells from various tissue samples, facilitating a deeper understanding of their molecular and phenotypic hallmarks.
Celentis makes a lasting impact on the future of aging research. Our advanced senescence sensors are the ideal tools for researchers seeking to unravel the mysteries of aging and pave the way for novel anti-aging therapies.
Celentis Senescence Sensors:
Unmatched Advantages and Features
Celentis Senescence Sensors empower researchers to break new ground in anti-aging research with their unique set of advantages and features:
Humane and Efficient Research: No Animal Sacrifice Required
Our in vivo senescence sensors eliminate the need for animal sacrifice, allowing researchers to conduct high-impact preclinical studies while minimizing animal suffering. This aligns with the growing trend of ethical research practices and animal welfare.
Precision and Certainty: Semicontinuous Quantification and Concurrent Staining
Our sensors provide accurate, semicontinuous quantification of senescent cells in animal models, enabling researchers to track changes over time and assess the efficacy of interventions. Additionally, the ability to apply other stains simultaneously ensures unequivocal identification of senescent cells.
Streamlined Workflow: Rapid Detection and Easy Sample Collection
Our sensors offer rapid detection of senescent cells, with measurements taking between 5 minutes and 2 hours, depending on the probe used. For monitoring senescent cell dynamics or treatment effects, urine samples can be collected and analyzed using a fluorimeter or IVIS®.
Innovative Technology: Addressing a Critical Challenge
Our sensor technology stands out as a unique solution to a critical challenge in anti-aging research: the lack of a universal senescent cell marker. Our sensors provide a reliable and standardized approach to senescent cell detection, facilitating reproducible and meaningful research.
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